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Topic Name: New Pain Killer with a much reduced side effect
Category: Biomedical
Research persons: Professor Lambert ,Professor of Anaesthetic Pharmacology ,Critical Care and Pain Management.
Location: Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester LE2 7LX., United Kingdom
Details
A potential new pain-killing drug developed by medical scientists at the
University of Leicester and Ferrara in Italy is to be discussed at a public
lecture on 20th March.
Professor David Lambert, who has been involved in the development the drug in
collaboration with Dr Girolamo Calo in Ferrara Italy, believes the new drug –
called UFP-101 - avoids many of the side effects of morphine, currently the
‘gold standard’ in pain reduction.
He said: “In a 2005 survey for the British Pain Society 975 people were
questioned about pain. Twenty one percent experienced pain every day or most
days equating to ~10million across the whole UK.
“Morphine produces its clinical effects by interaction with opioid receptors.
In addition to acting as a pain killer this drug produces a number of unwanted
side effects of importance from a clinical (e.g., depression of breathing,
constipation and tolerance) and social (addiction) viewpoints.
“Clearly there is a place for new morphine like drugs without these side
effects and the University of Leicester Anaesthesia Division has been at the
forefront of such preclinical research.”
Since appointment in 1991 as a lecturer Professor Lambert has been working on
opioids and opioid receptors with particular emphasis on understanding receptor
function and the design and evaluation of new drugs to target these receptors.
In collaboration with Dr Girolamo Calo his laboratory has characterised a
prototype analgesic (pain killer), acting at a new opioid receptor, with a much
reduced side effect profile.
In his inaugural lecture he will describe the current place of opioids in the
clinic and development of UFP-101.
Inaugural lecture at 5.30pm on 20th March, Ken Edwards Building, University
of Leicester
Note to Editors Professor David Lambert was the Edmund Riding Professor of
the Royal College of Anaesthetists, has been awarded the Humphrey Davy medal by
the same organisation and has received the Mapleson Medal from the UK
Anaesthetic Research Society. He is Editor of British Journal of Anaesthesia and
has published ~170 papers with a large proportion on opioids.
About Researcher:
Dave Lambert is Professor of Anaesthetic Pharmacology with laboratories based
at the Leicester Royal Infirmary. He joined the University Department in 1991
from the Department of Cell Physiology and Pharmacology.
Lambert DG on PubMed
Teaching:
Module leader MB ChB Special study module “Mechanism of action and clinical use
of opiates”
On-line
Primary FRCA Lecture by Dave Lambert now available, using this link.
Additional Duties:
-
Section editor and member of the editorial board of the British Journal of
Anaesthesia
-
BJA/RCA Grants Officer. Click on the following link for the
BJA/RCA
Grant/Fellowship Forms
-
Council member Anaesthetic Research Society and Hon. Treasurer
-
Member of the Pharmacology sub-committee European Society of Anaesthesiologists
Honours:
-
Elected Edmund Riding Professor of the Royal College of Anaesthetists
-
Awarded by the Royal College of Anaesthetists(as a non-anaesthetist) the Humphry
Davy Medal for services to Anaesthesia
-
Visiting Professor to Dept Anaesthesia of Hirosaki university, Japan 2001 and
2002
The Division of Anaesthesia, Critical Care and Pain
Management, Robert Kilpatrick Clinical Sciences Building, Leicester Royal
Infirmary, Leicester LE2 7LX. UK
- Tel: +44 (0)116 258 5291 x5694
- Fax: +44 (0)116 247 0141
- e-mail: DGL3@le.ac.uk
Funding:
Pfizer Ltd. Ph.D. studentship (Miss E Johnson) “Species
variation in nociceptin pharmacology” 01/11/2000-31/10/2003.
British Journal of Anaesthesia and UHL NHS trust.
“Characterisation of novel ligands with activity at the nociceptin receptor”
(Joint with Professor DJ Rowbotham) 01/07/01-30/06/03.
British Journal of Anaesthesia. Ph.D. studentship (Miss PMW
Lam) “Studies on the desensitization of the recombinant VR1 receptor”
 
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