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Many types of catechin in green tea called polyphenols that one group is included. These types of catechin in green tea is very astringent component of the antioxidant action of a lot of attention is being used in health foods. Also, included in the tea catechin is the main component of Type EPIGAROKATEKINGARETO (EGCG), the highest antioxidant activity, anti-viral activity, anti-cancer effects, such as antimicrobial action of various bioactive natural products as Collect. However, EGCG physiological conditions in the chemical structure of a low stability, is now resolved and the cell membrane that can result in a low affinity for the biologically active enough to not have problems such as exercise, medicine is limited in its application as . The烋Susumu Gen (human advancement) Associate Professor, Institute of Medical Sciences and Research Group, lipase (fatty acid ester hydrolysis enzymatic) to take advantage of the catalyst, EGCG in the fatty acids in the introduction to the chemical structure Affinity for cell membrane stability and has developed a method of increasing (Figure 1). And, EGCG fatty acid derivative, using a variety of inhibiting the growth of cancer cells, or head cancer tumor growth in mice and effectively succeeded in blocking it.
Summary of Achievements

Lipase catalyst used, EGCG to the carbon number 4, 8 and 16 of the straight-chain saturated fatty acids EGCG-modified fatty acid derivative (each EGCG-C4, EGCG-C8, EGCG-C16) were synthesized. For those of cancer cells and normal cells to examine the effect of inhibiting the growth of the mechanism of cell growth inhibition examined by biochemical methods. Human colon cancer cells, cancer cells (Caco-2) and mouse colon cancer cells (Colon26) was used as the normal cells of the rat vascular smooth muscle cells was used. EGCG is a physiological condition of the solution is oxidized easily resolved. When the hydrogen peroxide is known to occur. The hydrogen peroxide in the secondary as a contribution to the anti-cancer effects may be. To remove hydrogen peroxide and catalase enzymes that EGCG supplementation in the state could reduce cytotoxicity was also confirmed. The EGCG, synthetic fatty acid derivative occurred in the suppression of hydrogen peroxide, to improve the stability found. EGCG-C16 for the cell toxicity, cell toxicity in addition catalase reduced without the direct interaction of cells and suggests that has been enhanced. In addition, EGCG-C16 is toxic to cancer cells than normal cells were five times higher level. Including the use of the cancer cells, cancer cells in the epidermal growth factor receptor (EGFR) in excess of that expression has been found, EGCG-C16 will have the EGFR signaling cell growth by blocking the transmission of Cancer cells to apoptosis (suicide) is in the lead has been confirmed.
Then, a hypodermic Colon26 disseminated to the official in charge of the formation of cancer tumors in mice administered by the effect of inhibiting the growth of cancer tissue examined. EGCG is a natural show the most growth-inhibiting effect, EGCG-C16 to the remarkable size of a tumor suppressor that has been confirmed (Figure 2).

Research over the human drink regularly the most tea catechins in the simple efficient component of fatty acid in the introduction, with less side-effects of anti-cancer drugs can expect to be able to supply.


Glossary
fatty acids tea polyphenols are extracted from the name of the group. EPIKATEKIN, EPIGAROKATEKIN, and EPIGAROKATEKINGARETO. Antioxidant, anti-cancer activity, anti-allergy effect, a variety of physiological effects, such as antimicrobial activity have been reported.
Alcohol and fatty acids and fatty acid ester lipase hydrolyzing enzyme. The reverse reaction is the reaction of fatty acids and alcohol and fatty acid ester can be synthesized.
Long-chain fatty acids in the hydrocarbon value carboxylic acid 1
Anti-cancer drugs used in chemotherapy for a malignant tumor drug. There are various types of common side effects are a strong, specific to the cancer cells and reduce side effects in some studies have been thriving.
Epithelial growth factor receptor (EGFR)
EGFR in a variety of origins in the shape of the cell membrane protein expression in the epithelial growth factor (EGF) is activated by binding to the cell differentiation and proliferation, or to let them. On the other hand, EGFR in a variety of malignant tumors that were overexpressed, and the activation of EGFR-specific anti-cancer drugs that inhibit the research and development.

Kyoto Shimbun (November 27, two-plane), the Sankei Shimbun (November 27, 24-plane), the Nikkan Kogyo Shimbun (November 27, 34-plane), Mainichi Shimbun (November 27, three sides) and Yomiuri Shimbun (11 31 of 27) was published.

Figure 1 EGCG in animal experiments using mouse tumor growth inhibitory effect of derivatives.
(A) were transplanted into mouse skin changes in the volume of cancer cells. EGCG-C16 in the treatment group to dominate the growth of cancer cells was inhibited.
(B) a month after the transplant of cancer cells taken from mice of cancer, finding the naked eye. EGCG-C16 in the treatment group revealed a small tumor size can be confirmed.

fig-2From left to right: Institute of Medical Sciences Professor Susumu Gen Research associate Kazuaki Matsumura, open-Fat Institute of Scientific and Industrial Research, Osaka University Professor

Fig 3 fatty acid lipase introduced by the reaction of EGCG

Tags:	green tea polyphenols - anti-cancer - fatty acids - fatty acids - cancer cells -
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