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Topic Name: Responsible gene for asthma
Category: Genetic Engineering
Research persons: Dr. Thomas more freshly & His Team
Location: Vienna’s Medical University,A-1090 Vienna, Währinger belt 18, Austria
Details
An international team, which associated two Austrian organizations, highlighted the implication of a gene in the appearance of asthma during childhood. The gene is located on the 17th chromosome (17q21) and codes for protein ORMDL3.
Asthma is a disease which comprises genetic and environmental factors still badly included/understood. In this respect, the results published in the Nature review clear up the genetic share of the disease. Contrary to the initial suspicions, it seems that the genetic responsibility for the disease is assumed by a gene mainly, and not by several of equivalent importances.To arrive to these conclusions, the scientists had recourse to a panel of 2237 individuals, including 994 asthmatic. They systematically indexed the variations (or polymorphisms) of only one basic pair of the genome among the studied population, in nearly 317.000 places of the genome. In relation to the data healthy/sick they identified multiple markers located on gene of chromosome 17 coding for protein ORMLD3 like clearly associated asthma.
The future investigations should attempt to explore more in detail the role of protein ORMLD3. For the time being it proves that the protein with an action on the level of the endoplasmic reticulum, an organoid present in the cells eucaryotes.
About Researchers:Dr. Thomas more freshly
Univ.Klinik f. Child and youth medicineA-1090 Vienna, Währinger belt 18-20
Email: thomas.frischer@meduniwien.ac.atInternet: www.meduniwien.ac.at/kikli/
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