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Topic Name: New methods to avoid the infection of the AIDS
Category: Biomedical
Research persons: Santos Manes - Central Nacional de Biotecnología - C Darwin, 3
Location: Campus of Cantoblanco - 28.049 Madrid - Tel.: +34 915.854.500, fax: +34 915.854.506, Spain
Details
A team of the Higher Council of Scientific Research (CSIC) identified a new therapeutic way to avoid the cellular infection by the virus of the AIDS. This projection is important and makes it possible to include the initial phases of the infection by the HIV and could make it possible to slow down the evolution of the AIDS.
The researchers indeed found a molecule which is fixed on the receivers that the virus uses to enter the cells. The director of the team, Santos Mañes, explains that “each cell of the organization has a skeleton, the cytosquelette, which determines its form and provides the internal support necessary so that it functions. Vis-a-vis an attempt at infection, the cytosquelette reacts while reorganizing via a complex system which calls upon the enzymes Rho GTPasas”. During former research, the scientific team had noticed that the virus of the AIDS needed to activate enzyme RHO-A to enter the cell and to infect it. From these results, the team analyzed how enzyme RHO-A reacts when the virus is linked with the cell. This way led to a protein of union with the cytosquelette, Filamina A. the researchers discovered that this protein, in the event of infection, anchors the receivers of the virus to the cytosquelette of the cell and, simultaneously, activates enzyme RHO-AMañes emphasized the important role of Filamina A in the process of the infection of the AIDS: “the success of the virus of the AIDS to infect the cells of the immunological system, the lymphocytes T, lies certainly in the mechanism described in the study”.
From the data obtained in this study, the researchers concluded that the HIV adapts the physiological mechanism which activates the cells of defense of the organization, the lymphocytes T, to enter in them and to eliminate them. This process depends on the function of Filamina A which, when it enters in interaction with the receivers of the virus, replacement initiates a process of receivers. This process is very similar to that which occurs during the activation of the lymphocytes T.
About Researchers:
Dr. Santos Mañes, Department of Immunology and Oncology, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas, Universidad Autonoma, Campus de Cantoblanco, E-28049, Madrid, Spain. E-mail: smanes@samba.cnb.uam.es.
Funded:
Higher Council of Scientific Research (CSIC)
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