 |
|
|||||||||||||||||||||
 |
 |
|||||||||||||||||||||
| Date: 13 October 2008 | ||||||||||||||||||||||
|
||||||||||||||
Physicians understand the importance of \"First, Do No Harm.\" This critical phrase from the Hippocratic Oath emphasizes the physician’s responsibility to treat illness and disease without causing harm as a result of the treatment. Riboflavin, the key component in Mirasol PRT, is a non-toxic and non-mutagenic compound, and is ingested in normal diets. Navigant Biotechnologies\' primary goal is to use this technology to improve the safety of the world\'s blood supply without introducing the potential for harm.
Benefits of Mirasol PRTMirasol Pathogen Reduction Technology offers several key benefits to blood centers and physicians and their patients needing blood:
Mirasol PRT has been tested on a variety of pathogens implicated in transfusion transmitted diseases and has demonstrated significant pathogen load reduction. Pathogens that have been reported to be inactivated include:
Viruses
Enveloped
- Bovine Viral Diarrhea Virus (BVDV)
- Human Immunodeficiency Virus–1 (HIV-1) – Extracellular and
- Human Immunodeficiency Virus–1 (HIV-1) – Intracellular, ProviralCell Associated
- Pseudorabies
- Vesicular Stomatitis Virus (VSV)
Non-enveloped
- Canine Parvovirus
- Hepatitis A
- Porcine Parvovirus
Bacteria
Gram Positive
- B. cereus
- S. aureus
- S. epidermidis
Gram Negative
- E. coli
- K. pneumoniae
- P. aeruginosa
Parasites
- Plasmodium Falciparum (Malaria)
Other
- Graft versus Host Disease (GvHD)
- Jurkat Cell
Mirasol PRT System
The Mirasol PRT system from Navigant Biotechnologies is relatively simple. Riboflavin is mixed into a blood product which is then exposed to light for a short period of time – typically less than 10 minutes. This illumination causes a chemical reaction that prevents the DNA and RNA of the pathogen from replicating.
The nucleic acids DNA and RNA provide the instructions for copying and reproducing the pathogen. Viruses, bacteria and other cells with nuclei (e.g., white blood cells) are thus inactivated because they are unable to replicate and spread through the body. Red blood cells, platelets, and plasma, which lack nucleic acids, are not harmed.
The Mirasol PRT system currently does not require removal of residual riboflavin or photo products. This aspect of Mirasol PRT makes the process simple to perform. Following treatment, blood components are immediately ready to use.
Mirasol PRT Equipment and Disposables
Because Mirasol PRT is very simple, the only additional equipment required is an illuminator. No other equipment is needed for storage or cell washing. Currently the Mirasol PRT illuminator in development requires less than three linear feet of counter space. Navigant is working closely with blood centers to design a PRT system that meets the size and process requirements of the blood collection locations.
The disposable sets for Mirasol PRT will vary somewhat depending on the blood component. However the basic disposable sets will consist of a bag containing the riboflavin solution, a standard bag for component collection/mixing/illumination/storage, and (for red blood cells) a bag containing a nutrient solution to maintain cell quality.
" />
|
||||||||||||||||||||||||||||
|
||||||||||||||||||||||||||||
| Home | Members.Benefit | Privacy.Policy | Bookmark.This.Page | Contact.Us | ||||||||||||||||||||||||||||
| © 2006 - 2007 4engr. All Rights reserved |Recommended Engineering Sites:| Center for Respect of Life and Environment | Internet Dictionary|Enginering intent(Engineering Events) | Map Archive | ||||||||||||||||||||||||||||
