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Details of Alan M. Lambowitz

Biochemistry
Director, Institute for Cellular and Molecular Biology
Mr. and Mrs. A. Frank Smith, Jr. and Nancy Lee and Perry R. Bass Regents Chairs in Molecular Biology

Contact Information
Office
MBB 2.234
Office Phone
232-3418
Lab
MBB 2.234BA
Lab Phone
232-3419
Fax
232-3420

Education
BS, Brooklyn College, City University of New York (1968);   PhD, Yale University (1972); Postdoctorate, University of Pennsylvania, Rockefeller University, National Institutes of Health (1973-76)

Awards
Member, National Academy of Sciences (2004);   Texas Academy of Medicine, Engineering, and Scienc (2004);   Fellow, American Academy of Microbiology (2002);   Fellow, American Association for the Advancement of Science (2001);   UT Cooperative Society Award for Best Research Paper (2000);   American Academy of Arts and Sciences (1995);   NIH Merit Award (1993)
Research interests include: mechanisms of RNA catalysis, how proteins assist formation of RNA structure, mechanisms involved in intron mobility, the evolution of introns and splicing mechanisms, the origin of retroviruses and reverse transcription, and the development of novel methods for functional genomics and gene therapy.
Representative Publications
Mohr, S., Matsuura, M., Perlman, P.S., and Lambowitz, A.M.  "A DEAD-box protein by itself promotes group II intron splicing and reverse splicing by acting as an RNA chaperone." Proc. Natl. Acad. Sci., USA 103 (2006): 3569-3574.

Noah, J.W., Park, S., Whitt, J.T., Perutka, J., Frey, W., and Lambowitz, A.M.  "Atomic force microscopy reveals DNA bending during group II intron ribonucleoprotein particle integration into double-stranded DNA." Biochemistry 45 (2006): 12424-12435.

Paukstelis, P., Coon, R., Madabusi, L., Nowakowski, J., Monzingo, A., Robertus, J., and Lambowitz, A.M.  "A tyrosyl-tRNA synthetase adapted to function in group I intron splicing by acquiring a new RNA binding surface" Mol. Cell 17 (2005): 417-428.

Perutka, J., Wang, W., Goerlitz, D., and Lambowitz, A.M.  "Use of computer-designed group II introns to disrupt Escherichia coli DExH/D-box protein and DNA helicase genes" J. Mol. Biol. 336 (2004): 421-439.

Lambowitz, A.M., and Zimmerly, S.  "Mobile group II introns" Annu. Rev. Genet. 38 (2004): 1-35.

Mohr, S., Stryker, J., and Lambowitz, A.M.  "A DEAD-box protein functions as an ATP-dependent RNA chaperone in group I intron splicing" Cell 109 (2002): 769-779.