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The area in presynaptic terminals where the specialized secretory machinery for the focused release of neurotransmitters packaged in vesicles is concentrated (i.e. synapsin and related proteins). Under the electron micrograph these areas are recognized as sites where vesicles seem to be undergoing exocytosis (termed omega figures by Rene Couteaux). It is commonly observed that receptors for neurotransmitters are localized on the postsynaptic neuron in close proximity to active zones. This allows for extremely concentrated neuronal signal conduction, in contrast to endocrine cells which release hormones in a diffuse manner such that many cells are stimulated.
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